abstract：:To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before ...

journal_title：Frontiers of medicine

authors： Huang L,Xu A

更新日期：2017-03-01 00:00:00

abstract：:A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n = 25) or 20 mg (n = 38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in splee...

journal_title：Frontiers of medicine

authors： Du X,Zhou D

更新日期：2016-12-01 00:00:00

abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...

journal_title：Frontiers of medicine

authors： Wang X,Tan Y,Li Y,Li J,Jin W,Wang K

更新日期：2016-12-01 00:00:00

abstract：:This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The Hib polysaccharide was conjugated with the rPsaA protein carrier, which was produced using recombinant DN...

journal_title：Frontiers of medicine

authors： Chen Z,Guo R,Xu J,Qiu C

更新日期：2016-12-01 00:00:00

abstract：:NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) i...

journal_title：Frontiers of medicine

authors： Pan M,Zhang Q,Liu P,Huang J,Wang Y,Chen S

更新日期：2016-12-01 00:00:00

abstract：:This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute....

journal_title：Frontiers of medicine

authors： Ma Y,Zhang N,Wu S,Huang H,Cao Y

更新日期：2016-12-01 00:00:00

abstract：:Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent...

journal_title：Frontiers of medicine

authors： Wang L,Jiang S,Shi J,Gong S,Zhao Q,Jiang R,Yuan P,Pudasaini B,He J,Jing Z,Liu J

更新日期：2016-09-01 00:00:00

abstract：:Alternative splicing plays a fundamental role in the development and physiological function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative...

journal_title：Frontiers of medicine

authors： Wang Y,Liu Y,Nie H,Ma X,Xu Z

更新日期：2016-09-01 00:00:00

abstract：:The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein's half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps...

journal_title：Frontiers of medicine

authors： Liu Y,Liu C,Dong W,Li W

更新日期：2016-09-01 00:00:00

abstract：:A high level of social support can improve long-term diabetes self-management. Support from a single source has been evaluated. This study aims to analyze support from multiple and multilevel sources for diabetic patients by using the Chronic Illness Resources Survey (CIRS). Factors influencing the utilization of the ...

journal_title：Frontiers of medicine

authors： Zhong H,Shao Y,Fan L,Zhong T,Ren L,Wang Y

更新日期：2016-06-01 00:00:00

abstract：:Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided ...

journal_title：Frontiers of medicine

authors： Xia W,Liu F,Ma D

更新日期：2016-06-01 00:00:00

abstract：:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...

journal_title：Frontiers of medicine

authors： Wang J,Ma Z,Niu M,Zhu Y,Liang Q,Zhao Y,Song J,Bai Z,Zhang Y,Zhang P,Li N,Meng Y,Li Q,Qin L,Teng G,Cao J,Li B,Chen S,Li Y,Zou Z,Zhou H,Xiao X

更新日期：2015-12-01 00:00:00

abstract：:Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This metaanalysis included related published studies to address this concern. Eight databases in the literature until Fe...

journal_title：Frontiers of medicine

authors： Bu X,Yang L,Zuo Y

更新日期：2015-12-01 00:00:00

abstract：:Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...

journal_title：Frontiers of medicine

authors： Gitau SC,Li X,Zhao D,Guo Z,Liang H,Qian M,Lv L,Li T,Xu B,Wang Z,Zhang Y,Xu C,Lu Y,Du Z,Shan H,Yang B

更新日期：2015-12-01 00:00:00

abstract：:MicroRNAs (miRNAs), an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level. miRNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3...

journal_title：Frontiers of medicine

authors： Tsang FH,Au SL,Wei L,Fan DN,Lee JM,Wong CC,Ng IO,Wong CM

更新日期：2015-09-01 00:00:00

abstract：:Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo...

journal_title：Frontiers of medicine

authors： Luo Q,Chen Z,Cheng A,Wang M,Fang J,Peng X,Tang L

更新日期：2015-03-01 00:00:00

abstract：:At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms...

journal_title：Frontiers of medicine

authors： Wang Z,Hu Z,Wu J,Ji F,Wang H,Lai Y,Gao X,Ning Y,Zhang C,Li Z,Liang W,Liu J

更新日期：2015-03-01 00:00:00

abstract：:Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vasoocclusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is ...

journal_title：Frontiers of medicine

authors： Owusu-Ansah A,Choi SH,Petrosiute A,Letterio JJ,Huang AY

更新日期：2015-03-01 00:00:00

abstract：:Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this...

journal_title：Frontiers of medicine

authors： Gong W,Yan M,Chen J,Chaugai S,Chen C,Wang D

更新日期：2014-12-01 00:00:00

abstract：:This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patie...

journal_title：Frontiers of medicine

authors： Wang J,Liang B,Zhang X,Xu L,Deng X,Li X,Fang L,Tan X,Mao Y,Zhang G,Wang Y

更新日期：2014-09-01 00:00:00

abstract：:Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed. ...

journal_title：Frontiers of medicine

authors： Zhang R,Wang Y,Liu B,Song G,Zhou X,Fan S,Pan X

更新日期：2014-09-01 00:00:00

abstract：:Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recogn...

journal_title：Frontiers of medicine

authors： Zhou X,Li Y,Peng Y,Hu J,Zhang R,He L,Wang Y,Jiang L,Yan S,Li P,Xie Q,Liu B

更新日期：2014-09-01 00:00:00

abstract：:This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a fourcenter, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventiona...

journal_title：Frontiers of medicine

authors： Wang M,Li J,Li S,Xie Y

更新日期：2014-09-01 00:00:00

abstract：:The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently b...

journal_title：Frontiers of medicine

authors： Yang Y,Han X,Guan J,Li X

更新日期：2014-03-01 00:00:00

abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...

journal_title：Frontiers of medicine

authors： Fu Y,Wang X,Pan Z,Xie X

更新日期：2014-03-01 00:00:00

abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...

journal_title：Frontiers of medicine

authors： Liu X,Ren H,Peng D

更新日期：2014-03-01 00:00:00

abstract：:Cleft lip and palate (CLP) is the most common craniofacial congenital deformity. The etiology of CLP is multifactorial and involves complex interactions between environmental and genetic factors. Millard's rotation advancement technique has long been considered as state-of-the-art for unilateral cleft lip repair. Howe...

journal_title：Frontiers of medicine

authors： Xu Y,Li J,Shi B

更新日期：2013-12-01 00:00:00

abstract：:Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decad...

journal_title：Frontiers of medicine

authors： Zhang C,Bao Z,Zhang W,Jiang T

更新日期：2013-06-01 00:00:00

abstract：:Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease. ...

journal_title：Frontiers of medicine

authors： Liao E

更新日期：2013-03-01 00:00:00

abstract：:Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple ...

journal_title：Frontiers of medicine

authors： Miao X,Sun W,Fu Y,Miao L,Cai L

更新日期：2013-03-01 00:00:00

abstract：:It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...

journal_title：Frontiers of medicine

authors： Zhao Y,Zeng D

更新日期：2013-03-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without ...

journal_title：Frontiers of medicine

authors： Chen X,Huang X,Qiu Y,Chen H,Fu Y,Li X

更新日期：2013-03-01 00:00:00

abstract：:Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although th...

journal_title：Frontiers of medicine

authors： Gao J,Panizza B,Johnson NW,Coman S,Clough AR

更新日期：2012-12-01 00:00:00

abstract：:Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, th...

journal_title：Frontiers of medicine

authors： Wang JH

更新日期：2012-09-01 00:00:00

abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...

journal_title：Frontiers of medicine

authors： Liu S,Li J,Lv Y

更新日期：2012-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...

journal_title：Frontiers of medicine

authors： Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J

更新日期：2012-06-01 00:00:00

abstract：:Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, rece...

journal_title：Frontiers of medicine

authors： Shang B,Cao Z,Zhou Q

更新日期：2012-03-01 00:00:00

abstract：:Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...

journal_title：Frontiers of medicine

authors： Wei J,Feng J

更新日期：2011-12-01 00:00:00

abstract：:Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulat...

journal_title：Frontiers of medicine

authors： Cui H

更新日期：2011-09-01 00:00:00

abstract：:At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management...

journal_title：Frontiers of medicine

authors： Wang S,Yu H,Liu J,Liu B

更新日期：2011-06-01 00:00:00